The need for an integrated approach to studying relationally aggressive behavior is evident, considering the growing though scattered and fragmentary research documenting the predictors and outcomes of this behavior. In the current paper a comprehensive review of the extant literature concerning relationally aggressive behavior of adolescents is presented, taking into account the conclusive evidence supporting the prevalence of relational aggression during this developmental stage. It opens with a conceptual clarification of the term and discussion of the theoretical approaches to the study of this aggressive form of behavior. It focuses on the main findings of the relevant theory and empirical research providing insight into both individual and contextual antecedents as well as the correlates of relationally aggressive behavior. Assessment methods for identifying relational aggression in children and adolescents are described, with an emphasis on measurement techniques most sustainable for capturing this sometimes-intangible construct. The article concludes with a discussion of proposed best practices for effectively preventing and responding to incidents of relational aggression within the context of social and emotional learning, positive behavioral or family-based interventions. Recommendations for future investigations with reference to the current theoretical conceptualizations and empirical findings on relational aggression are advanced.